Having obtained a degree in Costume and Fashion Design from the Accademia di Costume e di Moda di Roma, he then specialized in textiles and knitwear. Early in his career, Nassos worked in film and television. He then took that experience and applied the skills to the world of high fashion. He has collaborated with some of the biggest names in the fashion industry, both in Greece and around the world.
In 2011, Nassos launched the Nassos Ntotsikas brand. Soon afterwards, he won the Best Trendsetter Award at the Athens Exclusive Designers Week. In 2013, he unveiled his Bridal Collection. By the start of 2014, Nassos had opened his own atelier in Athens. His atelier is a space for creative expression and experimentation: it is where he makes his dreams reality. Nassos recently launched his second line, Pure | Nassos Ntotsikas.